Endocrine Abstracts

Introduction: Glucocorticoids are used for treatment of various hematological malignancies such as Acute Myeloid Leukemia (AML). Glucocorticoids are known to induce apoptosis by regulating the expression of key anti- or pro-apoptotic genes. Vitamin D induces apoptosis and cell cycle arrest in various types of cancer cells. Despite recent advances in treatment of AML, the poor response rate to therapy remains a big challenge.Therefore, discovering new factors that can affect th...